Role of mechanosensitive Piezo ion channel in kidney disease
10.3760/cma.j.cn441217-20240614-00623
- VernacularTitle:机械敏感离子通道Piezo在肾脏疾病中的作用
- Author:
Weiwei LI
1
;
Zhaowei CHEN
1
;
Guohua DING
1
Author Information
1. 武汉大学人民医院肾内科，武汉 430060
- Publication Type:Journal Article
- Keywords:
Ion channels;
Mechanoreceptors;
Kidney glomerulus;
Kidney tubules;
Piezo
- From:
Chinese Journal of Nephrology
2025;41(2):154-160
- CountryChina
- Language:Chinese
-
Abstract:
Piezo is a newly discovered mechanosensitive ion channel (MSC) in mammals, characterized by a unique homotrimeric three-leaf propeller-shaped structure that converts mechanical signals into biological and electrical signals, thus participating in the regulation of various physiological and pathological processes. In recent years, an increasing number of studies have demonstrated the crucial role of Piezo channel in renal physiology and pathophysiology. This article aims to provide new perspectives and targets for the prevention and treatment of renal diseases by reviewing the recent research advances in the structure, kinetics and pharmacology of Piezo channel, especially their expression and physiopathologic roles in the kidney.
