Expression of c-erbB2, CyclinD1, and Akt1 proteins in papillary thyroid carcinoma tissue
10.3760/cma.j.cn231583-20240614-00174
- VernacularTitle:甲状腺乳头状癌组织c-erbB2、CyclinD1、Akt1蛋白表达研究
- Author:
Xiao HAN
1
;
Wei FAN
;
Qian XU
;
Dongshun JIA
;
Fei HU
;
Cheng HANG
Author Information
1. 江苏省淮安市肿瘤医院病理科，淮安 223200
- Publication Type:Journal Article
- Keywords:
Papillary thyroid carcinoma;
Human epidermal growth factor receptor 2;
CyclinD1;
Protein kinase B1
- From:
Chinese Journal of Endemiology
2024;43(12):954-958
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the protein expression of human epidermal growth factor receptor 2 (c-erbB2), CyclinD1, and protein kinase B1 (Akt1) in papillary thyroid carcinoma tissue.Methods:A retrospective study was conducted to collect papillary thyroid carcinoma tissues, adjacent tissues, pathological and medical records, as well as one year follow-up data of patients ( n = 117) diagnosed with papillary thyroid carcinoma at Huai'an Cancer Hospital in Jiangsu Province from January 2021 to October 2022. The protein expression of c-erbB2, CyclinD1, and Akt1 were determined by immunohistochemistry. The positive rates of c-erbB2, CyclinD1, and Akt1 proteins in cancerous tissue and adjacent tissues, and cancerous tissue of patients with different clinical features and recurrence status were compared. Results:There were statistically significant differences in the positive rates of c-erbB2 [36.75% (43/117) vs 5.98% (7/117)], CyclinD1 [47.86% (56/117) vs 6.84% (8/117)], and Akt1 proteins [64.96% (76/117) vs 11.97% (14/117)] between the cancerous tissue and adjacent tissue of patients with papillary thyroid carcinoma (χ 2 = 32.96, 49.55, 69.41, P < 0.001). There were statistically significant differences in the positive rates of c-erbB2, CyclinD1, and Akt1 proteins in cancerous tissues of patients with different tumor node metastasis (TNM) classification staging, invasion of the capsule, and lymph node metastasis (χ 2 = 40.67, 20.47, 12.07, 13.68, 7.25, 9.16, 22.04, 27.18, 46.31, P < 0.05). There was no statistically significant difference in the positive rates of c-erbB2, CyclinD1, and Akt1 proteins in cancerous tissues of patients with different genders, ages, smoking history, drinking history, maximum tumor diameter, and whether the tumor was multifocal or accompanied by Hashimoto's thyroiditis ( P > 0.05). The follow-up results of 117 patients with papillary thyroid carcinoma showed that there were 15 cases of recurrence and 102 cases of no recurrence. The positive rates of c-erbB2, CyclinD1, and Akt1 proteins in the cancerous tissue of the recurrence group were higher than those of the non recurrence group (χ 2 = 4.00, 4.47, 6.09, P < 0.05). Conclusion:The positive rates of c-erbB2, CyclinD1, and Akt1 proteins in papillary thyroid carcinoma tissues are relatively high, and are closely related to TNM classification staging, invasion of the capsule, lymph node metastasis, and recurrence.
