The Progresses of Multi-omics Technologies in The Study of Antibiotic Resistance in Cronobacter
10.13865/j.cnki.cjbmb.2025.07.1052
- VernacularTitle:多组学技术在克罗诺杆菌耐药性研究中的应用
- Author:
Xian-Pei ZHU
1
;
Bin NIU
;
Jie-Lin YANG
Author Information
1. 上海大学生命科学学生物技术实验室331,上海 210095
- Publication Type:Journal Article
- Keywords:
antibiotic resistance;
multi-omics technologies;
cronobacter
- From:
Chinese Journal of Biochemistry and Molecular Biology
2025;41(11):1590-1599
- CountryChina
- Language:Chinese
-
Abstract:
This review aims to summarize the progress of multi-omics technologies in the study of antibi-otic resistance in Cronobacter,with the goal of gaining a deep understanding of its resistance mechanisms and providing a scientific basis for the development of new treatment methods and prevention strategies.By integrating genomics,transcriptomics,proteomics,and metabolomics,the study analyzes gene varia-tions,expression patterns,protein function changes,and metabolic pathway adjustments in Cronobacter.This includes the use of whole-genome sequencing to reveal gene variations related to antibiotic resist-ance,RNA-seq technology to monitor changes in gene expression patterns,proteomics to study protein expression and function,and metabolomics to analyze dynamic changes in metabolites.The research has found that factors such as biofilm formation and outer membrane proteins significantly affect the antibiotic resistance of Cronobacter.In addition,new potential influencing factors have been identified,including the expression changes of multidrug efflux pump genes,which may play a key role in enhancing antibiotic efflux and reducing intracellular antibiotic concentrations.Multi-omics technologies provide a comprehen-sive and in-depth perspective for the study of antibiotic resistance in Cronobacter,revealing multiple fac-tors and potential mechanisms that affect resistance.Although some new influencing factors have been i-dentified,their specific molecular mechanisms still require further investigation.The application pros-pects of multi-omics technologies are broad,and they are expected to provide important support for the development of new treatment methods and prevention strategies.
