The effect of tranexamic acid and hemocoagulase on postoperative bleeding in adult patients with Kashin-Beck disease undergoing total knee arthroplasty
10.3760/cma.j.cn231583-20231128-00120
- VernacularTitle:氨甲环酸和巴曲亭对成人大骨节病全膝关节置换术后出血量的影响
- Author:
Wanbao TUO
1
;
Guanwen LIANG
;
Yanxiang ZHANG
;
Long YANG
;
Yinyu LYU
;
Qichun SONG
Author Information
1. 宝鸡市人民医院骨二科，宝鸡 721000
- Publication Type:Journal Article
- Keywords:
Kashin-Beck disease;
Knee arthroplasty;
Tranexamic acid;
Hemocoagulase;
Postoperative bleeding;
Postoperative drainage volume;
Occult blood loss
- From:
Chinese Journal of Endemiology
2025;44(1):47-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the effect of two hemostatic drugs, tranexamic acid and hemocoagulase, on postoperative bleeding in adult patients with Kashin-Beck disease undergoing total knee arthroplasty.Methods:A retrospective analysis was conducted to select 80 adult patients with Kashin-Beck disease who underwent unilateral primary total knee arthroplasty at Linyou County Hospital from January 2021 to March 2023. According to the inclusion and exclusion criteria, 19 cases with chronic anemia, long-term oral anticoagulants implanted with cardiac stents, and hematological diseases were excluded. Among the remaining 61 adult patients, 24 cases with preoperative intravenous application combined with intraoperative local application of tranexamic acid in articular cavity were selected as the experimental group, and 37 cases with preoperative intravenous application combined with intraoperative local application of hemocoagulase in articular cavity were selected as the control group. The preoperative general condition, postoperative drainage volume, total perioperative blood loss, occult blood loss, and hemoglobin levels at different time points before and after surgery were compared between the two groups of patients.Results:There was no statistically significant difference in age, gender distribution, body mass index, preoperative hemoglobin level, preoperative prothrombin time, and preoperative activated partial thromboplastin time between the two groups of patients ( P > 0.05). The total perioperative blood loss [(1 027.78 ± 472.71) ml], drainage volume 48 h after surgery [(336.67 ± 112.74) ml] in the experimental group were all lower than those in the control group [(1 390.39 ± 454.01), (498.65 ± 187.57) ml], and the differences were statistically significant ( P < 0.05). The hemoglobin levels on the second and fifth day after surgery were significantly higher than those in the control group, and the differences were statistically significant ( P < 0.05). Conclusion:For total knee arthroplasty for adult patients with Kashin-Beck disease, preoperative intravenous application combined with intraoperative local application of tranexamic acid in articular cavity is superior to hemocoagulase, which can effectively reduce total perioperative blood loss and postoperative drainage volume, and is worthy of clinical promotion.
