Pathological diagnosis and research progress of HPV-independent vulvar intraepi-thelial neoplasia
10.13315/j.cnki.cjcep.2025.11.002
- VernacularTitle:HPV不相关性外阴鳞状上皮内肿瘤的病理诊断和研究进展
- Author:
Lihua ZHANG
1
Author Information
1. 东南大学附属中大医院病理科,南京 210000
- Publication Type:Journal Article
- Keywords:
vulvar intraepithelial neoplasms;
verrucous/spinous hyperplasia;
vabnormal vulvar maturation;
HPV;
p53
- From:
Chinese Journal of Clinical and Experimental Pathology
2025;41(11):1405-1410
- CountryChina
- Language:Chinese
-
Abstract:
HPV-independent vulvar intraepithelial neoplasia is rare and often develop vulvar squamous cell carci-noma in a short period of time or at the same time,and is the most common pre-lesion of vulvar squamous cell carcino-ma.HPV-independent vulvar intraepithelial neoplasia is significantly different in pathogenesis,pathological morpholo-gy,molecular characteristics,clinical treatment and prognosis.HPV-independent vulvar intraepithelial neoplasia is di-verse in morphology and can be divided into differentiated vulvar intraepithelial tumors and verrucous/acanthogenic in-traepithelial tumors/abnormal vulvar maturation,including TP53 gene mutant and wild type.HPV-independent vulvar intraepithelial neoplasia often occurs on the basis of chronic skin inflammation,and are easily confused with chronic dermatitis and squamous epithelial reactive hyperplasia.Correlation with the clinical,selecting appropriate immunohis-tochemical markers or molecular testing can help diagnose the disease.
