Research progress on neuroimaging mechanisms of rumination in post-traumatic stress disorder
10.3969/j.issn.1002-0152.2025.10.009
- VernacularTitle:反刍思维在创伤后应激障碍中神经影像学机制研究进展
- Author:
Jiaen LIN
1
;
Shuya YAN
;
Licheng GAN
;
Shuming ZHONG
;
Yanbin JIA
Author Information
1. 暨南大学附属第一医院精神医学科(广州 510630);暨南大学管理学院
- Publication Type:Journal Article
- Keywords:
Rumination;
Post-traumatic stress disorder;
Neuroimaging;
Default mode network;
Prefrontal-limbic system;
Magnetic resonance imaging;
Glutamate;
γ-aminobutyric acid
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(10):632-636
- CountryChina
- Language:Chinese
-
Abstract:
Rumination is a core cognitive symptom of post-traumatic stress disorder(PTSD),which significantly exacerbates difficulties in emotional regulation and impedes symptom recovery.Its occurrence is closely associated with gray matter structural impairments and abnormal white matter connectivity in the prefrontal-limbic system,including the hippocampus,amygdala,and prefrontal cortex.Functional neuroimaging studies indicate that the neural basis of rumination involves hyperactivation of the default mode network and the salience network,coupled with reduced functionality of the executive control network.Neurochemical research suggests that metabolic imbalances in the glutamate/γ-aminobutyric acid system may further contribute to the maintenance and reinforcement of rumination.Systematically elucidating the neural mechanisms of rumination in PTSD patients based on multimodal neuroimaging evidence will facilitate a deeper understanding of its neuropathological mechanisms and help expand future research directions.
