Preoperative plasma adiponectin predicts electroconvulsive therapy response in patients with depression
10.3969/j.issn.1002-0152.2025.10.004
- VernacularTitle:治疗前血浆脂联素预测抑郁症患者电休克治疗反应研究
- Author:
Shaoxing WANG
1
;
Zhiguo LI
;
Jiaxuan HUANG
;
Xinyi LIU
;
Xinxin ZHENG
;
Yanqing ZHANG
Author Information
1. 山西医科大学麻醉学院(太原 030001)
- Publication Type:Journal Article
- Keywords:
Adiponectin;
Depression;
Electroconvulsive therapy;
Biomarker;
Prediction;
Treatment outcome
- From:
Chinese Journal of Nervous and Mental Diseases
2025;51(10):601-607
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the potential role of plasma adiponectin concentration in predicting the response of patients with depression to electroconvulsive therapy(ECT).Methods This study enrolled depressive patients scheduled for ECT at the First Hospital of Shanxi Medical University between January 2022 and March 2024.Patients were categorized as either ECT responders(>50%reduction)or non-responders(≤50%reduction)based on post-ECT reduction rate of the 24-item Hamilton depression scale(HAMD)scores from baseline.Plasma adiponectin levels were measured in all patients before their first ECT treatment.To identify predictors of ECT response in patients with depression,the predictive value of plasma adiponectin was evaluated using receiver operating characteristic(ROC)curve analysis.Results A total of 80 patients with depression were enrolled including 44 in the ECT-responsive group and 36 in the non-responsive group.The plasma adiponectin level was significantly higher in the responsive group than in the non-responsive group[5.67(3.64,10.55)μg/mL vs.4.01(2.59,5.04)μg/mL,P=0.002].Pearson correlation analysis revealed a significant positive correlation between plasma adiponectin levels and the HAMD reduction rate(r=0.300,P=0.007).Multivariate logistic regression analysis showed that plasma adiponectin was independently associated with the response to ECT in patients with depression(OR=1.218,95%CI:1.009-1.470,P=0.040).Furthermore,ROC curve analysis demonstrated that the area under the curve(AUC)for adiponectin in predicting ECT response was 0.748(95%CI:0.583-0.813).Conclusion Pretreatment plasma adiponectin may serve as a potential biomarker for predicting response to ECT in patients with depression.
