Application and Progress of Vonoprazan in Maintenance Therapy of Gastroesophageal Reflux Disease
10.3969/j.issn.1008-7125.2025.03.005
- VernacularTitle:伏诺拉生在胃食管反流病维持治疗中的应用与进展
- Author:
Kehan YIN
1
;
Xinyuan WANG
1
;
Bo WANG
1
;
Shengliang CHEN
1
Author Information
1. 上海交通大学医学院附属仁济医院消化内科 上海市消化疾病研究所(200001)
- Publication Type:Journal Article
- Keywords:
Vonoprazan;
Gastroesophageal Reflux Disease;
Maintenance Therapy;
Safety
- From:
Chinese Journal of Gastroenterology
2025;30(3):173-176
- CountryChina
- Language:Chinese
-
Abstract:
Gastroesophageal reflux disease(GERD)is a chronic recurrent disorder characterized by typical symptoms such as acid regurgitation and heartburn.Its high recurrence rate and long-term complications not only significantly impact patients' quality of life but also impose a heavy healthcare burden.Traditional proton pump inhibitors(PPIs),as first-line therapeutic agents,are often inadequate for long-term maintenance therapy of GERD due to shortcomings such as short half-life,susceptible to genetic polymorphisms,and nocturnal acid breakthrough.Recently,the potassium-competitive acid blocker(P-CAB)vonoprazan has demonstrated advantages increasingly in the maintenance therapy of GERD.This article reviewed the research progress on vonoprazan in the maintenance therapy of GERD,aiming to provide a reference for optimizing the long-term management of GERD.
