Association between glycated albumin/hemoglobin A1c ratio and type 2 diabetes mellitus with metabolic associated fatty liver disease
10.3969/j.issn.1006-6187.2025.11.009
- VernacularTitle:糖化白蛋白/糖化血红蛋白比值与2型糖尿病合并代谢相关脂肪性肝病相关性的研究
- Author:
Rui JIN
1
;
Yujing SHA
1
;
Chenyu HAN
1
;
Caijuan SHENG
1
;
Yongfang FANG
1
;
Min ZHANG
1
Author Information
1. 201799 上海,复旦大学附属中山医院青浦分院内分泌科
- Publication Type:Journal Article
- Keywords:
Glycated albumin/hemoglobin A1c;
Diabetes mellitus,type 2;
Metabolic associated fatty liver disease;
Mediation analysis
- From:
Chinese Journal of Diabetes
2025;33(11):845-849
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between glycated albumin/hemoglobin A1c(GA/HbA1c)and type 2 diabetes mellitus(T2DM)complicated with metabolic associated fatty liver disease(MAFLD).Methods A total of 502 hospitalized T2DM patients were enrolled between January 2022 and December 2023 and divided into T2DM group(n=301)and combined with MAFLD(MAFLD,n=201)group.Clinical data were collected,and Logistic regression analyses were performed to evaluate the relationship between GA/HbA1c and MAFLD.Mediation analysis was conducted to assess the role of blood lipids.Results The MAFLD group had higher levels of drinking,waist-to-hip ratio,body mass index,fasting insulin,fasting C-peptide,insulin resistance index,alanine aminotransferase,aspartate aminotransferase,triglycerides(TG),small dense low-density lipoprotein(sdLDL),and blood uric acid compared to the T2DM group(P<0.05).The age,DM duration,GA,GA/HbA1c,and high-density lipoprotein cholesterol(HDL-C)were lower in the MAFLD group than in the T2DM group(P<0.05).Logistic regression analysis showed that after adjusting for confounding factors,GA/HbA1c was an influencing factor for the occurrence of MAFLD in T2DM patients.Mediation analysis revealed that TG,sdLDL,and HDL-C had significant mediating effects,accounting for 19.3%,12.4%,and 8.5%of the risk association,respectively.Conclusions GA/HbA1c is influencing factor of MAFLD in T2DM patients,with blood lipids showing significant mediating effects,suggesting that GA/HbA1c may serve as a novel indicator for assessing MAFLD risk.
