To explore the curative effect of tangerine peel compound on chicken Eimeria tenella disease
10.16303/j.cnki.1005-4545.2025.10.22
- VernacularTitle:探究陈皮复方对雏鸡柔嫩艾美耳球虫病的疗效
- Author:
Junze CHENG
1
;
Chenchen WANG
1
;
Qi ZHANG
1
;
Huixin LIU
1
;
Qiyuan ZHAO
1
;
Ting ZHANG
1
;
Zong-gu XIE
1
;
Hongbin SI
1
Author Information
1. 广西大学 动物科学技术学院广西畜禽繁育与疾病防控重点实验室/广西牧草工作站,广西南宁 530004
- Publication Type:Journal Article
- Keywords:
chicken coccidiosis;
Chinese herbal medicine;
tangerine peel;
inflammation;
pathway;
close connection
- From:
Chinese Journal of Veterinary Science
2025;45(10):2264-2272,2281
- CountryChina
- Language:Chinese
-
Abstract:
The study explored the therapeutic effect and mechanism of the compound composed of tangerine peel,plum,agrimony and hawthorn on Eimeria tenella in chicks.In the experiment,144 chicks were divided into six groups:the blank group,the model group,the diclazuril group,and the high-dose,medium-dose and low-dose traditional Chinese medicine compound groups.The 14-day-old chickens were infected,the body weight and mortality were recorded,and the samples were dis-sected at 21 days of age.The anticoccidial effect of Chenpi compound at different doses was evalua-ted by calculating anticoccidial index,feed conversion rate and detecting serum cytokine levels and related mRNA expression levels.The results showed that the anticoccidial index of the middle dose group was 172.86,and the anticoccidial index of the low dose group was 158.98.In the middle and low dose groups,the levels of IL-1β,IL-6 and MDA in serum decreased significantly,while the levels of IL-4,IL10,T-AOC,SOD,CAT and GSH-Px increased significantly,and the mRNA ex-pression levels of related inflammation and antioxidant pathways changed.Further studies found that the medium-dose compound can regulate the ChTLR15/ChMyD88/ChNF-κB/ChNLRP3/Caspase-1 inflammatory signaling pathway,activate the Nrf2/Keap1/HO-1 antioxidant signaling pathway,and enhance the body's anti-inflammatory and antioxidant capacity;at the same time,it can increase the expression of intestinal tight junction ZO-1 and Occludin,repair the damaged in-testinal barrier,and play an anticoccidial role.The results showed that the middle dose of tangerine peel compound had a good effect in the treatment of coccidiosis,and its mechanism involved the regulation of anti-inflammatory and antioxidant pathways.
