Revision of the concept of anti-angiogenesis and its applications in tumor treatment
- Author:
Yang WEN-HUI
1
;
Xu JUN
;
Mu JIAN-BING
;
Xie JUN
Author Information
1. Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, Shanxi 030001, China;Tumor Hospital of Shanxi Province, Taiyuan, Shanxi 030013, China
- Publication Type:Journal Article
- Keywords:
Anti-angiogenesis;
Angiogenesis;
Vascular endothelial growth factor;
Cancer
- From:
Chronic Diseases and Translational Medicine
2017;3(1):33-40
- CountryChina
- Language:English
-
Abstract:
Anti-angiogenesis therapy, by blocking formation of new blood vessels in tumors, is the standard-of-care therapy for various cancer types. The classic concept of anti-angiogenesis is expected to turn a tumor into a "dormant" disease. However, the com-bination of anti-angiogenesis agents with conventional therapeutics has generally produced only modest survival benefits for cancer patients in clinical trials. Therefore, the concept and applications of anti-angiogenesis have evolved dramatically along with lessons learned from recent clinical experience. In this article, we will discuss the revised concept of anti-angiogenesis therapy and the applications of anti-angiogenesis drugs, and focus particularly on how to utilize current anti-angiogenesis agents and develop new approaches to provide more benefits to patients with cancer.
