Analysis of one case of suspected leukemic reaction caused by inosine injection
10.12173/j.issn.1005-0698.202405064
- VernacularTitle:疑似肌苷注射液致类白血病反应1例分析
- Author:
Yixin HUANG
1
;
Qinwen ZHU
1
;
Yifan WU
1
;
Xinyan LIU
1
Author Information
1. 上海交通大学医学院苏州九龙医院药学部(江苏苏州 215028)
- Publication Type:Journal Article
- Keywords:
Inosine injection;
Leukemic reaction;
Adverse drug reactions
- From:
Chinese Journal of Pharmacoepidemiology
2025;34(4):480-484
- CountryChina
- Language:Chinese
-
Abstract:
A 34-year-old female patient with multiple injuries in a car accident was admitted to hospital and received inosine injection.After 11 days,leukemioid reaction mainly characterized by"abnormal increase in white blood cell count"occurred,and the white blood cell count reached up to 38.26×109·L-1.Considering that inosine injection was the cause,the white blood cell count gradually decreased to 15.84×109·L-1 after the drug was stopped.Naranjo's assessment scale was used to evaluate the association of adverse reactions,with a score of 6,and the result was"very likely to be relevant".The cases reported in this paper belong to new adverse reactions caused by inosine injection,suggesting that inosine injection as an adjunct should pay attention to drug safety.If there is an abnormal increase in white blood cell count,it is necessary to be alert to the possibility of"leukemioid reaction"and stop the drug in time if necessary.
