Effect of icilin on MPTP-induced nerve damage in Meriones unguiculatus

VernacularTitle:Icilin对MPTP诱导的长爪沙鼠神经损伤的影响
Author: Xiyu GAO ¹ ; Shoupeng FU ; Aohan YAN ; Yue SUN ; Shuo YANG ; Yiming ZHANG ; Dian-feng LIU ; Dewei HE
Author Information

1. 吉林大学动物科学学院,吉林长春 130062
Publication Type:Journal Article
Keywords: icilin; Meriones unguiculatus; nerve damage; microglia
From: Chinese Journal of Veterinary Science 2025;45(5):1053-1059
CountryChina
Language:Chinese
Abstract: Parkinson's disease(PD)is the second most prevalent neurodegenerative disease and a major cause of movement disorders.Neuroinflammation plays an important role in the pathogenesis of PD.Icilin is a small molecule compound that has been reported to inhibit inflammation.Howev-er,its role in PD has not been reported.This study explored the effects of icilin on motor behavior,nerve damage,microglia activation,and neuroinflammation in MPTP-induced PD Meriones unguic-ulatus by behavioral experiments,immunohistochemistry,Western blot,and fluorescence quantifi-cation.The results showed that Icilin not only ameliorated motor dysfunction and neurological damage in MPTP-induced Meriones unguiculatus,but also inhibited microglia hyperactivation and its mediated neuroinflammation.The present study provides an evidence that icilin attenuates MPTP-induced neurodegenerative lesions in long-pawed gerbils,suggesting that it is a promising candidate for PD.