Butorphanol Combined with Esketamine for the Treatment of Remifentanil Induced Hyperalgesia after laparoscopic Gynecological Surgery:A Randomized Double-Blind Controlled Trial
10.13241/j.cnki.pmb.2025.10.008
- VernacularTitle:布托啡诺复合艾司氯胺酮治疗腹腔镜妇科手术后瑞芬太尼痛觉过敏:一项随机双盲对照试验
- Author:
Xian-cai LI
1
;
Gui-wen ZHANG
1
;
Yi JIANG
1
Author Information
1. 辽宁省健康产业集团阜新矿总医院麻醉科 辽宁阜新 123000
- Publication Type:Journal Article
- Keywords:
Butorphano;
Esketamine;
Laparoscopic gynecological surgery;
Remifentanil;
Hyperalgesia;
Randomized double-blind controlled trial
- From:
Progress in Modern Biomedicine
2025;25(10):1667-1675
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the effect of combine treatment of butorphanol combined with esketamine in patients with remifentanil induced hyperalgesia after laparoscopic gynecological surgery.Methods:Based on randomized double-blind controlled trial,120 patients undergoing laparoscopic gynecological surgery in our hospital from April 2023 to October 2024 were divided into control group 1(received esketamine treatment,n=40),control group 2(received butorphanol treatment,n=40),and study group(received butorphanol combined with esketamine treatment,n=40).The awakening time,extubation time,mean arterial pressure(MAP),heart rate(HR),visual pain analog scale(VAS)score,ramsay sedation score,and incidence of adverse reactions among three groups were compared.Results:The awakening time and extubation time in the study group were shorter than those in the control group 1 and control group 2(P＜0.05).The MAP and HR in the study group were lower than those in the control group 1 and control group 2 at 30 minutes,60 minutes after extubation(P＜0.05).The VAS scores in the study group were lower than those in the control group 1 and control group 2 at 30 minutes,60 minutes after extubation(P＜0.05).The ramsay sedation scores in the study group were higher than those in the control group 1 and control group 2 at 30 minutes,60 minutes after extubation(P＜0.05).There was no significant difference in the incidence of postoperative adverse reactions among the three groups(P＞0.05).Conclusion:Butorphanol combined with esketamine can further alleviate remifentanil induced hyperalgesia after laparoscopic gynecological surgery,exert good sedative and analgesic effects,maintain hemodynamic stability,and have good safety.
