Hypertension and angina pectoris caused by sorafenib
10.3760/cma.j.issn.1008-5734.2015.06.016
- VernacularTitle:索拉非尼致高血压和心绞痛
- Author:
Xinfeng ZHANG
1
;
Cuixia QIAO
;
Xufeng CHENG
;
Huaizhang WANG
;
Xuchu YANG
;
Qilong GAO
Author Information
1. 450008,郑州大学附属肿瘤医院中西医科
- Publication Type:Journal Article
- Keywords:
Sorafenib;
Hypertension;
Angina pectoris
- From:
Adverse Drug Reactions Journal
2015;(6):457-459
- CountryChina
- Language:Chinese
-
Abstract:
A 57-year-old male patient received oral sorafenib 400 mg twice daily for pulmonary metastases after operation of thyroid carcinoma. About 3 and a half months of treatment,the patient experienced dizziness,pain in the anterior region of the heart and blood pressure of 180 / 105 mmHg(before treatment it was 120 / 75 mmHg). He received oral metoprolol administration(initial dose of 25 mg twice daily,gradually increased to 200 mg twice daily). About one and a half months later,he received sustained release capsules of isosorbide mononitrate 50 mg once daily because of the intermittent attack of precordial pain. Angina pectoris still occurred frequently. He underwent percutaneous coronary intervention twice(a total of 2 stents implantation). Hypertension and angina pectoris were still poorly controlled. On month 19 of sorafenib treatment,the dose of drug was reduced to 400 mg once daily. His blood pressure was 135 / 85 mmHg but angina still occurred intermittently. On month 22,sorafenib was stopped. Two months later,the patient's blood pressure declined to 130 / 80 mmHg,and the frequency of angina pectoris decreased. Four months after the termination of sorafenib,his blood pressure was 120 / 75 mmHg and no episode of angina pectoris occurred.
