Research progress in coronavirus enzyme targets and drug screening methods
10.3969/j.issn.1002-2694.2025.00.043
- VernacularTitle:冠状病毒酶靶标药物及其筛选方法研究进展
- Author:
Hui-ke FENG
1
;
Wen-qing YANG
;
Jian-ru QIN
;
Gang-gang YANG
;
Xian-guang YANG
Author Information
1. 河南师范大学生命科学学院,新乡 453007;抗病毒性传染病创新药物全国重点实验室,新乡 453007;平原实验室,新乡 453007
- Publication Type:Journal Article
- Keywords:
coronavirus;
viral enzymes;
antiviral agent;
drug screening methods
- From:
Chinese Journal of Zoonoses
2025;41(3):304-312
- CountryChina
- Language:Chinese
-
Abstract:
Coronavirus,a major pathogen infecting humans,mammals,and birds,causes primarily respiratory diseases af-ter infecting humans.Seven coronaviruses have been found to infect humans and subsequently cause varying degrees of respira-tory symptoms.From 2019 to 2023,millions of people died from severe acute respiratory syndrome coronavirus 2 infections,and the virus continues to mutate.Therefore,drug screening research must urgently be expanded to develop more effective,broad-spectrum anti-coronavirus drugs.In-depth research has indicated that the coronavirus 3C-like protease and RNA polymer-ase are necessary for viral reproduction and are highly conserved among strains,and consequently are anti-virus targets of great interest.This article summarizes the enzymes encoded by coronaviruses and drug screening methods,to provide a reference for coronavirus prevention and control.
