QT interval prolongation and type I hypersensitivity reaction caused by orally taken moxifloxacin
10.3760/cma.j.issn.1008-5734.2014.06.013
- VernacularTitle:莫西沙星片致 QT 间期延长和速发型变态反应
- Author:
Dengke OU
1
;
Xiaoming ZHOU
;
Yu CHEN
;
Limei ZHAO
;
Li ZHAO
Author Information
1. 中国医科大学附属盛京医院呼吸内科, 沈阳,110004
- Publication Type:Journal Article
- Keywords:
Moxifloxacin;
Hypersensitivity immediate;
QT interval prolongation
- From:
Adverse Drug Reactions Journal
2014;(6):372-373
- CountryChina
- Language:Chinese
-
Abstract:
Mezlocillin sodium and sulbactam sodium for injection(2. 5 g,once every 12 hours)and azithromycin injection(0. 5 g,once daily)were given to a 23-year-old female patient due to the community-aquired mycoplasma pneumonia and acute purulent tonsillitis. On the eleventh day,the treatments above mentioned were changed to oral moxifloxacin 0. 4 g once daily because of the improvement of the patient's condition. Thirty minutes after the moxifloxacin administration for the first time,the patient felt chest tightness,palpitation,fever,and generalized flush accompanied by wheal and papula on her limbs and trunk. The electrocardiogram examination showed double directional or inverted T waves in the precordial leads and prolonged QT period with corrected QT interval 462 ms. Laboratory examination showed creatine kinase(CK)239 U/ L,isoenzyme of creatine kinase(CK-MB)35 U/ L. TypeⅠhypersensitivity reaction was diagnosed. Moxifloxacin was stopped and ananaphylaxis and supportive treatments were given immediately. Three days later,her skin symptoms disappeared,ECG examination result returned to normal. The levels of CK and CK-MB were 40 U/ L and 11 U/ L,respectively.
