Tacrolimus-induced glucose metabolic disorder in a patient with membranous nephropathy
10.3760/cma.j.issn.1008-5734.2013.04.013
- VernacularTitle:他克莫司致膜性肾病患者糖代谢紊乱
- Author:
Hai-yan LAO
1
;
Bo WAN
;
Min YANG
;
Shuang-xin LIU
Author Information
1. 广东省医学科学院广东省人民医院药学部,广州,510080
- Publication Type:Journal Article
- Keywords:
Tacrolimus;
Nephropathy,membranous;
Glucose metabolism disorders
- From:
Adverse Drug Reactions Journal
2013;15(4):220-221
- CountryChina
- Language:Chinese
-
Abstract:
A 72-year-old man received oral tacrolimus 2 mg twice daily and methylprednisolone 8 mg once daily for atypical membranous nephropathy.About six months later,the patient presented with anepithymia,dry mouth,and asthenia.Laboratory testing showed a fasting blood-glucose level of 23.2mmol/L and a glycosylated hemoglobin level of 13.1％.The diagnose was considered more likely to be druginduced secondary diabetes mellitus.Tacrolimus was stopped and changed to oral mycophenolate mofetil 500 mg every 12 hours.And methylprednisolone was continued according to the original dosage and telmisartan and insulin were given at the same time.Four days later,his glucose level became stable relatively.
