Literature Analysis of Bleeding Adverse Drug Reaction Induced by Apixaban
10.3870/j.issn.1004-0781.2025.06.025
- VernacularTitle:阿哌沙班致出血不良反应文献分析
- Author:
Rongrong WANG
1
;
Qiaoyun WANG
1
;
Meijuan SUN
1
;
Xiangpeng LI
1
;
Na LI
1
;
Ping LENG
1
Author Information
1. 青岛大学附属医院药学部,青岛 266000
- Publication Type:Journal Article
- Keywords:
Apixaban;
Bleeding;
Adverse drug reactions;
Literature analysis
- From:
Herald of Medicine
2025;44(6):989-995
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the occurrence and clinical characteristics of bleeding adverse reactions induced by apixaban,and to provide reference for clinical therapy.Methods From the marking of apixaban to May 2024,cases of adverse reactions to hemorrhage caused by apixaban were searched in the database of CNKI,Wanfang,VIP,PubMed and Web of Science.Statistical analysis was performed on the collected data.Results A total of thirty-nine cases of hemorrhagic adverse reactions induced by apixaban were documented.Therewere thirty-three patients(84.62%)over 60 years old.Twenty-two patients had bleeding within 30 days of treatment(56.41%).Intracranial hemorrhage occurred in nine patients(23.08%).Twenty-two patients improved after conventional treatment(56.41%).Twenty-three patients(58.97%)stopped bleeding within 30 days,and two patients(5.13%)died,all of whom died within 1 month after taking apixaban.Conclusions Physician and pharmacists should pay close attention to the adverse reactions of hemorrhage caused by apixaban,and do a good job in drug monitoring and patient education to ensure the safety of clinical medication.
