Analysis of irrational drug use in adverse reaction reports of Chinese patent medicines
10.3760/cma.j.issn.1008-5734.2014.05.006
- VernacularTitle:中成药不良反应报告中不合理用药情况分析
- Author:
Xiaoling WU
1
;
Minhua ZHOU
;
Jianxiong DENG
Author Information
1. 广东省中西医结合医院药学部, 广东省佛山市,528200
- Publication Type:Journal Article
- Keywords:
Traditional Chinese patent drugs;
Irrational drug use
- From:
Adverse Drug Reactions Journal
2014;(5):281-285
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the effect of rational use of traditional Chinese patent medicines on medication safety. Methods By using cluster sampling method,the adverse drug reaction (ADR)reports about traditional Chinese patent medicines(including traditional Chinese medicine for injections)derived from the Center for ADR Monitoring of Guangdong from January 1st,2011 to December 31st,2011,were collected and retrospectively analyzed. The information of the patients' gender,ages, primary diseases,the suspected drugs causing ADR,drug combination,and the situation of ADR occurrence were collected. The situation of irrational drug use in these reports at 7 aspects such as indications, syndrome differentiation treatment,medication methods,dosage,combination of traditional Chinese patent medicines,concomitant use of the traditional Chinese medicines and the Western medicines,and suitability of medication were analyzed according to the protocol of evaluation standards of traditional Chinese patent medicine prescription and the rate of irrational drug use were calculated. Results A total of 283 reports in accordance with the inclusion criteria were collected,which comprised 283 patients. Of them,150 were male and 133 were female with ages from 2 months to 88 years and an average age was(44 ± 23)years. The primary diseases ranking at the top three were respiratory system disease( 71 patients ),nervous system disease(45 patients),and musculoskeletal system disease(42 patients). The traditional Chinese patent medicines involved in these reports were mainly antipyretic-detoxicating agents,blood activating and stasis removing agents,and reinforcing agents. The rates of irrational drug use associated with indications, medication methods,dosage,combination of traditional Chinese patent medicines,concomitant use of the traditional Chinese medicines and the Western medicines,and suitability of medication were 27. 2%(77/283), 6. 0%(17/283),7. 1%(20/283),5. 3%(15/283),6. 7%(19/283),0. 7%(2/283),respectively. Fifteen patients'medication(46. 8%)did not fit the syndrome differentiation classification among the 32 reports whose differentiation of syndromes could be identified. Conclusions The irrational drug use has marked effect on medication safety of traditional Chinese patent medicines and maybe one of the important factors in relation to adverse reactions induced by traditional Chinese patent medicines. In clinical use of traditional Chinese patent medicines,syndrome differentiation treatment should be the primary principle,medication beyond the indications should be avoided,more attention should be paid to usage and dosage of the drugs, and combination of function-similar traditional Chinese patent medicines and pharmacological action-similar traditional Chinese and Western medicines should be used cautiously.
