Effects of hyperbaric oxygen on vascular endothelial growth factor and connexin 43 in random skin flaps of rabbits

VernacularTitle:高压氧对家兔随意皮瓣血管内皮生长因子和缝隙连接蛋白的影响
Author: Xue-hua LIU ¹ ; Rui-nian YANG ; Fu-jia LIU ; Kun-hua GUO ; Hong-ying ZHAO ; Chun-jin GAO
Author Information

1. 首都医科大学附属北京朝阳医院高压氧科,北京,100020
Publication Type:Journal Article
Keywords: Hyperbaric oxygen; Skin flaps; Vascular endothelial growth factor (VEGF); Connexin 43(CX43)
From: Chinese journal of nautical medicine and hyperbaric medicine 2009;16(2):88-91
CountryChina
Language:Chinese
Abstract: Objective To explore effects and mechanism of hyperbaric oxygen (HBO) on capillary proliferation of random skin flaps in rabbits. Methods Random skin flap models were developed on the back of rabbits and HBO was administered to rabbits in the HBO group. Capillary density and contents of VEGF, CX43 were observed on the 3rd day and the 7th day respectively. Results Capillary density of the animals in the HBO group were higher than those in the control group on the 3rd day (P<0.05) and the 7th day (P<0.01) respectively. The content of VEGF in the HBO group was higher than that in the control group on the 3rd day and the 7th day (P<0.05). The contents of CX43 in the HBO group were higher than that in the control group on 3rd day (P<0.01) and the 7th day (P<0.05) respectively. Conclusions One of the mechanisms of HBO might be that higher expression of VEGF and CX43 promoted capillary proliferation in random skin flaps.