Hot Melt Extrusion Coupled with 3D Printing Technology in the Development of Ibuprofen Pharmaceutical Cocrystal Preparation
10.3870/j.issn.1004-0781.2025.06.010
- VernacularTitle:热熔挤出联合3D打印技术开发布洛芬药物共晶新制剂
- Author:
Mingchao YU
1
;
Xue LI
;
Wen NI
;
Jiaxiang ZHANG
Author Information
1. 中国海洋大学医药学院,青岛 266100;青岛海洋生物医药研究院制剂研发中心,青岛 266100
- Publication Type:Journal Article
- Keywords:
Pharmaceutical cocrystal;
Hot melt extrusion;
Structural characterization;
3D printing
- From:
Herald of Medicine
2025;44(6):900-905
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the development of new formulations new pharmaceutical cocrystal by combining hot melt extrusion and 3D printing technologies.Methods The insoluble drug ibuprofen and nicotinamide were selected as model drugs,and hot melt extrusion was applied to extrude ibuprofen-nicotinamide cocrystal by regulating the processing temperature,screw speed and residence time,etc.Hot-stage polarized light microscopy,powder X-ray diffraction,differential scanning calorimetry,Fourier transform infrared spectroscopy,and Raman spectroscopy were used for characterization analysis.The process research was carried out by investigating properties such as eutectic particle size and distribution,angle of repose,and vibrational solidity density.On this basis,two 3D printing techniques,fused deposition molding and selective laser sintering type,were selected for pharmaceutical cocrystal loaded sheet printing.Results A new formulation of pharmaceutical cocrystal tablets loaded with ibuprofen-nicotinamide was successfully printed through the combined application of hot-melt extrusion and 3D printing technologies.Conclusions Combined process of hot melt extrusion and 3D printing technology in the field of developing new pharmaceutical cocrystal formulations,laying the material foundation and scientific support for the development of new pharmaceutical cocrystal formulations with personalized and programmable release on demand.
