Thiamazole-induced lupus
10.3760/cma.j.issn.1008-5734.1014.04.016
- VernacularTitle:甲巯咪唑致药物性狼疮
- Author:
Zhenghan LI
1
;
Donghong WU
1
;
Binhua XU
1
;
Jie LIU
1
;
Liping WANG
1
Author Information
1. 150010哈尔滨市第一医院内分泌科
- Publication Type:Journal Article
- Keywords:
Methimazole;
Antithyroid agents;
Drug-induced lupus
- From:
Adverse Drug Reactions Journal
2014;(4):245-247
- CountryChina
- Language:Chinese
-
Abstract:
A 35-year-old female patient received oral thiamazole 10 mg twice daily,vitamin B4 10 mg thrice daily,and two tablets of batilol tablets(50 mg per tablet)thrice daily for hyperthyroidism. On week 1 of medication,because of decreasing level of white blood cells,thiamazole was reduced to 10 mg once daily and four tablets of berbamine hydrochloride tablets thrice daily were added to the regimen. On day 16 of medication,the patient experienced fever with a peak temperature of 37. 8 ℃ and red rash and itching on the limbs followed by generalized arthralgia. On day 10,slight swelling and positive tenderness appeared on proximal interphalangeal joints of index fingers and middle fingers of both hands,and metacarpopha-langeal joints of right index finger and middle finger. Positive tenderness also appeared on her both wrist joints,both ankle joints,and bilateral knee joints. Laboratory tests revealed the following values:erythrocyte sedimentation rate 41 mm/1 h,C-reactive protein 31 mg/L,antinuclear antibodies( ANA)1 :310,and anti-histone antibodies( AHA)( ﹢). Thiamazole was stopped while the other drugs were continued as before. Subsequently,the symptoms of pain and swelling of her joints gradually improved. After half a year of drug withdrawal,the ANA and AHA became negative.
