Anaphylactic shock due to somatostatin for injection
10.3760/cma.j.issn.1008-5734.2014.03.018
- VernacularTitle:注射用生长抑素致过敏性休克
- Author:
Li QIN
1
;
Miao LIU
1
;
Rongrong WU
1
;
Mingxue CAO
1
;
Hong ZHU
1
;
Hui XIA
1
;
Fengqun LIU
1
Author Information
1. 解放军第三〇二医院药学部,北京,100039
- Publication Type:Journal Article
- Keywords:
Somatostatin;
Anaphylaxis;
Shock
- From:
Adverse Drug Reactions Journal
2014;(3):180-181
- CountryChina
- Language:Chinese
-
Abstract:
A 51-year-old male hepatitis B patient with decompensated liver cirrhosis received IV infusions of somatostatin 3 mg for continuous 12 hours,lansoprazole 30 mg every 12 hours,vitamin K1 10 mg once daily due to upper gastrointestinal hemorrhage. The IV infusions of vitamin K1 and lansoprazole were completed within 2 hours and the patient did not present discomfort symptoms. About 2. 5 hours after the IV infusion of somatostatin,the patient developed chills and dyspnea. Somatostatin was withdrawn immediately. About 10 minutes later,he lost consciousness and had no response to voice stimuli. His heart rate was 160 times/min,respiratory rate was 32 breaths/min,and blood pressure undetectable. He was treated with oxygen mask. Intravenous dexamethasone 10 mg, subcutaneous injection of epinephrine 1 mg and intramuscular injection of promethazine 25 mg were given. About 20 minutes later,the patient slowly began to regain consciousness,but still had listlessness and apathy. His symptoms such as chills and dyspnea disappeared 1. 5 hours later,and then his heart rate was 110 times/min,respiratory rate was 23 breaths/min,and blood pressure was 109/50 mmHg. His therapy was changed to octreotide acetate 0. 5 mg in 0. 9%sodium chloride injection 60 ml every 12 hours via IV pump,lansoprazole and vitamin K1 were continued, the similar symptoms did not recur.
