Impact of camellia honey on high-fat diet-induced intestinal inflammation and injury in Drosophila
10.3969/j.issn.1005-4847.2025.04.008
- VernacularTitle:茶花蜜对高脂饮食果蝇模型生物学特征的影响
- Author:
Lili ZHANG
1
;
Shuqiong CAO
;
Mengting XU
;
Tao HONG
;
Meifang ZHANG
;
Dan LIU
;
Tao LUO
;
Zhiyong LIU
Author Information
1. 江西中医药大学实验动物科技中心,南昌 330004;江西省儿童医院,南昌 330006
- Publication Type:Journal Article
- Keywords:
camellia honey;
intestine;
high-fat diet;
Drosophila;
bio-phenotype
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(4):540-548
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effects of camellia honey on intestinal inflammation and injury induced by a high-fat diet(HFD)in Drosophila.Methods A HFD model group of fruit flies was created by feeding with standard culture medium containing 30％lard.Each camellia honey groups were fed the same high-fat medium containing different concentrations of camellia honey.The body mass,eclosion rate,climbing ability,size of lipid droplets,and levels of intestinal reactive oxygen species in adult flies were measured and analyzed.Results Compared with the model group,each camellia honey groups showed significant improvements.Specifically,camellia honey ameliorated the following HFD-induced alterations:decline in eclosion rate,increase in pupal volume,increase in adult average body mass,decrease in adult climbing ability,enlargement of the lipid droplet area,elevation in intestinal ROS levels,and intestinal damage.Conclusions Camellia honey improved the growth and development,intestinal inflammation,and injury induced by a HFD in Drosophila.
