Analysis of neuroelectrophysiology, TNF- β gene polymorphism and characteristics of Th22 and Tfh cells in peripheral blood of patients with Guillain-Barre syndrome
10.3760/cma.j.cn431274-20240530-00871
- VernacularTitle:吉兰-巴雷综合征患者神经电生理、 TNF- β基因多态性及外周血Th22、Tfh细胞特征分析
- Author:
Yu DENG
1
;
Li GONG
;
Hongyan LI
Author Information
1. 新疆维吾尔自治区人民医院神经内科，乌鲁木齐 830000
- Publication Type:Journal Article
- Keywords:
Guillain-Barre syndrome;
Neuroelectrophysiology;
Tumor necrosis factor-β;
T-helper 22 cells;
Follicular helper T cells
- From:
Journal of Chinese Physician
2025;27(6):901-905
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the neuroelectrophysiology, tumor necrosis factor -β ( TNF- β) gene polymorphism, and the characteristics of T helper 22 cells (Th22) and follicular helper T cells (Tfh) in peripheral blood of patients with Guillan-Barre syndrome (GBS). Methods:One hundred and twenty patients with GBS who were treated in People′s Hospital of Xinjiang Uygur Autonomous Region from January 2021 to December 2023 were selected as the observation group, and one hundred healthy individuals who underwent physical examinations in our hospital during the same period were selected as the control group. The differences in TNF- β gene polymorphism in peripheral blood and the characteristics of Th22 and Tfh cells in peripheral blood between the two groups were compared. Meanwhile, the differences in neuroelectrophysiology, peripheral blood TNF- β gene polymorphism, and peripheral blood Th22 and Tfh cell characteristics among patients with different severity levels in the observation group were analyzed. Results:There were statistically significant differences in TNF- β genotypes and alleles between the observation group and the control group (all P<0.05). The proportions of TNF- β1/1 and 1/2 genotypes and the proportion of TNF- β1 alleles in the observation group were 67.50% and 44.17%, respectively. The ratios of Th22 cells and Tfh cells were (1.23±0.34)% and (7.23±1.12)% respectively, which were significantly higher than those of the control group (all P<0.05). In the observation group, the conduction rates of the common peroneal nerve and the motor conduction rates of the tibial nerve in severe patients were (38.12±4.48)m/s and (32.23±3.88)m/s respectively, which were significantly lower than those in mild patients (all P<0.05). The abnormal rate of distal complex muscle action potential amplitude in severe patients of the observation group was 33.33%, which was significantly higher than that in mild patients ( P<0.05). In the observation group, the ratios of Th22 cells and Tfh cells in severe patients were (1.43±0.21)% and (8.01±1.02)% respectively, which were significantly higher than those in mild patients (all P<0.05). There was no statistically significant difference in neuroelectrophysiological indicators and the ratios of Th22 and Tfh cells in peripheral blood among patients with different TNF- β genotypes in the observation group (all P>0.05). Conclusions:Compared with the healthy population, the polymorphism of TNF- β gene and the characteristics of Th22 and Tfh cells in peripheral blood in patients with GBS were significantly abnormal, and the neuroelectrophysiology and the characteristics of Th22 and Tfh cells in peripheral blood were associated with the severity of the disease.
