Observation of fundus multimodal imaging features in patients with acute Vogt-Koyanagi-Harada syndrome

Xiufen YANG; Taoran ZHANG; Ran YOU; Xi CHEN; Mingming LI; Yingxiang HUANG

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Observation of fundus multimodal imaging features in patients with acute Vogt-Koyanagi-Harada syndrome

VernacularTitle:急性期福格特-小柳-原田综合征患者眼底多模态影像特征观察
Author: Xiufen YANG ¹ ; Taoran ZHANG ¹ ; Ran YOU ¹ ; Xi CHEN ¹ ; Mingming LI ¹ ; Yingxiang HUANG ¹
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1. 首都医科大学附属北京友谊医院眼科，北京　100050
Publication Type:Journal Article
Keywords: Vogt-Koyanagi-Harada syndrome; Frequency domain optical coherence tomography; Fundus fluorescein angiography; Indocyanine green angiography
From: Journal of Chinese Physician 2025;27(6):890-895
CountryChina
Language:Chinese
Abstract: Objective:To analyze the clinical manifestations and fundus multimodal imaging features of patients with acute Vogt-Koyanagi-Harada (VKH) syndrome, and provide a reference for early diagnosis of VKH syndrome.Methods:Retrospective analysis was performed on the clinical data and related examinations including spectral-domain optical coherence tomography (SD-OCT), fundus fluorescein angiography (FFA), and indocyanine green angiography (ICGA) of patients diagnosed with acute VKH syndrome in the Ophthalmology Department of the Beijing Friendship Hospital from January 2017 to December 2022.Results:A total of 17 patients (34 eyes) with acute VKH syndrome were included. SD-OCT showed exudative retinal detachment in all 34 eyes with punctate hyperreflective signals; 26 eyes had choroidal folds, and 14 patients (28 eyes) had " septum-like" structures under the neuroepithelium. FFA early images showed late retinal fluorescence pooling in a multi-lake pattern in all 34 eyes. ICGA was performed in 15 patients (30 eyes), with early images showing hyperfluorescence of choroidal vessels in all 30 eyes; 26 eyes had scattered hypofluorescent lesions in the fundus. Mid-to-late images showed blurred boundaries of choroidal vessels in 28 eyes.Conclusions:Patients with acute VKH syndrome have characteristic manifestations in SD-OCT, FFA, and ICGA. Fundus multimodal imaging can provide important references for the diagnosis of VKH syndrome.