"State-Target Differential Diagnosis and Treatment"in management of patten of qi sinking and blood stasis of coronary heart disease with angina pectoris
10.3969/j.issn.1006-2157.2025.05.002
- VernacularTitle:基于"态靶辨治"论治冠心病心绞痛气陷血瘀证
- Author:
Xinyi ZHOU
1
;
Di XIE
;
Yanpi LI
;
Zihan WANG
;
Haozhe XIONG
;
Li HUANG
;
Xiaoyan LU
Author Information
1. 北京中医药大学 北京 100029
- Publication Type:Journal Article
- Keywords:
State-Target Differential Diagnosis and Treatment;
pattern of qi sinking and blood stasis;
coronary heart disease;
angina pectoris;
Shengxian Quyu Decoction
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(5):599-604
- CountryChina
- Language:Chinese
-
Abstract:
Coronary heart disease with angina pectoris,characterized by myocardial ischemic injury as its fundamental pathological mechanism,represents a prevalent cardiovascular condition.The"State-Target Differential Diagnosis and Treatment"presents a holistic regulatory framework,integrating macroscopic state regulation with microscopic targeting.Guided by this approach,the pathological evolution of coronary heart disease is examined through four dimensions:"state-target-cause-effect."The"cause"encompasses both the pathogenesis and etiological factors of traditional Chinese and Western medicine.The"effect"manifests as adverse cardiovascular events,including myocardial infarction and heart failure.The"state"delineates the progressive development pattern of qi to blood to deficiency,beginning with qi stagnation and cold congealment in the initial stage,followed by blood stasis and phlegm obstruction in the intermediate stage,and culminating in qi-blood deficiency in the advanced stage.The"target"encompasses multi-level therapeutic interventions addressing both symptomatic manifestations and clinical indicators.Building on this theoretical foundation,this research focuses on the pattern of qi sinking and blood stasis commonly observed in late-stage angina,systematically elucidating its state regulation and targeting therapeutic strategies.Using the clinical empirical formula Shengxian Quyu Decoction as the baseline state prescription,an in-depth investigation was conducted to determine optimal combination patterns of symptom-and biomarker-targeted medications.This study aims to establish a modernized differential treatment system for angina pectoris with the pattern of qi sinking and blood stasis,providing novel research perspectives and theoretical foundations for enhancing clinical efficacy and reducing the risk of cardiovascular events.
