Neutropenia and fever induced by esomeprazole sodium for injection
10.3760/cma.j.issn.1008-5734.2017.04.014
- VernacularTitle:注射用艾司奥美拉唑钠致中性粒细胞减少伴发热
- Author:
Airong TANG
1
;
Wei SHEN
1
Author Information
1. 解放军三〇七医院消化内科, 北京,100071
- Publication Type:Journal Article
- Keywords:
Omeprazole;
Neutropenia;
Fever
- From:
Adverse Drug Reactions Journal
2017;19(4):298-299
- CountryChina
- Language:Chinese
-
Abstract:
A 58-year-old female patient with sour regurgitation, pyrosis, nausea, and vomiting received an IV infusion of esomeprazole sodium for injection 40 mg once daily.Before treatment, her white blood cell (WBC) count was 4.5×109/L and neutrophil (NEUT) count was 2.8×109/L.On day 2 of medication, her WBC was 3.4 ×109/L and NEUT 1.7×109/L.On day 7, the patient′s WBC was 2.1×109/L and NEUT 0.1×109/L.On day 10, her WBC was 1.6 ×109/L and NEUT 0×109/L, she developed chillness and fever (38.4 ℃).On day 11, her temperature reached 40 ℃ with throat discomfort.She was diagnosed with neutropenia combined with upper respiratory infection due to esomeprazole sodium for injection.Esomeprazole sodium for injection was stopped and meropenem for anti-infection and recombinant human granulocyte colony-stimulating factor for increasing neutrophil were given at the same day.On day 3 of drug withdrawal, her temperature descended to 36.4 ℃.On day 4, her WBC was 2.3×109/L and NEUT 0.8×109/L.On day 10, her WBC increased to 8.0 ×109/L and NEUT 4.9×109/L.
