Analysis of the clinical characteristics and sputum antibacterial protein levels of patients with cough variant asthma due to deficiency of different Zang-Fu organs
10.3760/cma.j.cn431274-20240412-00633
- VernacularTitle:不同脏腑虚损咳嗽变异性哮喘患者的临床特征及痰液抗菌蛋白水平分析
- Author:
Yongwei ZHAO
1
;
Jianjiang LUO
Author Information
1. 新疆医科大学第四临床医学院，乌鲁木齐 830000
- Publication Type:Journal Article
- Keywords:
Cough-variant asthma;
Deficiency of internal organs (Zang-Fu);
Airway surface fluid
- From:
Journal of Chinese Physician
2025;27(4):527-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the clinical characteristics and sputum antibacterial protein levels of patients with cough-variant asthma (CVA) due to deficiency of different Zang-Fu organs.Methods:A total of 109 patients with CVA admitted to the Department of Respiratory, Affiliated Hospital of Traditional Chinese Medicine, Xinjiang Medical University from January 2023 to June 2024 were selected. According to the deficiency and damage of the internal organs of the patients, they were divided into 45 cases in the lung qi deficiency group, 39 cases in the lung and spleen deficiency group, and 25 cases in the lung and kidney deficiency group. Thirty healthy individuals were taken as the normal control group. The general information of the subjects was collected. The disease course of CVA patients, the number of acute exacerbations and hospitalizations, the Asthma Control Test (ACT) score, the Traditional Chinese Medicine (TCM) syndrome score, and the results of pulmonary function tests [forced vital capacity (FVC), forced expiratory volume in one second (FEV 1), FEV 1/FVC, early peak expiratory flow rate (MEF 25), mid-peak expiratory flow rate (MEF 50), late peak expiratory flow rate (MEF 75)], and the levels of antibacterial proteins [β -defensin (β-DF), antimicrobial peptide LL-37, lysozyme (LZM), lactoferrin (LTF)] in the sputum of the subjects were detected by enzyme-linked immunosorbent assay. Results:There were no statistically significant differences in the disease course, the number of acute exacerbations and the number of hospitalizations among the three groups of CVA patients (all P>0.05). There were statistically significant differences in the ACT scores and TCM syndrome scores among the three groups of CVA patients ( F=82.221, 194.577, all P<0.05). Among them, the ACT score was in the order of lung Qi deficiency group>lung and spleen deficiency group>lung and kidney deficiency group, and the TCM syndrome score was in the order of lung qi deficiency group0.05), while there was a statistically significant difference in MEF 25 ( Z=53.896, P<0.05). Among them, the MEF 25 in the lung and kidney deficiency group was significantly lower than that in the lung qi deficiency group and the lung and spleen deficiency group (all P<0.05). The contents of β-DF, antimicrobial peptide LL-37, LZM and LTF in the sputum of the three groups of CVA patients were all higher than those in the normal control group (all P<0.05). Among them, the content of LZM in sputum of the lung and kidney deficiency group was higher than that of the lung and spleen deficiency group, and the content of antimicrobial peptide LL-37 was lower than that of the lung and spleen deficiency group. The differences were statistically significant (all P<0.05). Conclusions:The clinical characteristics of patients with CVA due to deficiency of different Zang-Fu organs are different, providing a theoretical basis for the syndrome differentiation and treatment of CVA by Zang-Fu organs. The level of antibacterial protein in sputum of the CVA group was higher than that of the normal control group. This might be because the onset of CVA is often induced by infection.
