The relationship between the monocyte/high-density lipoprotein cholesterol ratio, alkaline phosphatase, and all-cause mortality in maintenance peritoneal dialysis patients
10.3760/cma.j.cn431274-20240508-00763
- VernacularTitle:单核细胞/高密度脂蛋白胆固醇比值、碱性磷酸酶与维持性腹膜透析患者全因死亡的关系
- Author:
Zhanfeng JIAO
1
;
Yiming ZHANG
1
;
Nana LUO
1
;
Xiang LI
1
;
Xiaofen MA
1
;
Xia WANG
1
Author Information
1. 济宁医学院附属医院肾内科，济宁 272029
- Publication Type:Journal Article
- Keywords:
Peritoneal dialysis;
All-cause death;
Monocytes;
Cholesterol, HDL;
Alkaline phosphatase
- From:
Journal of Chinese Physician
2025;27(5):699-702
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the correlations between the monocytes/high-density lipoprotein ratio (MHR), alkaline phosphatase (ALP), and all-cause mortality in patients undergoing maintenance peritoneal dialysis (PD), and to provide references for clinical prevention and treatment strategies.Methods:A retrospective analysis was conducted on the clinical data of 336 PD patients who were treated in the Affiliated Hospital of Jining Medical University from June 2014 to August 2023. According to the survival status of the patients during the follow-up period, they were divided into the death group ( n=55) and the survival group ( n=281). The differences in clinical data, blood routine, laboratory biochemical indicators, monocyte count, high-density lipoprotein cholesterol, and ALP indicators between the two groups were collected and compared. Multivariate Cox regression analysis was used to screen the risk factors for all-cause mortality in PD patients, and Pearson correlation analysis was used to evaluate the correlation between the survival time of patients and related indicators. Results:In this study, there were 55 patients who died of all causes. The causes of death were cardiovascular events in 26 cases (47.27%), gastrointestinal bleeding in 3 cases (5.45%), infection in 7 cases (12.73%), multiple organ failure in 8 cases (14.55%), and unexplained death in 11 cases (20.00%). There was no statistically significant difference in gender, age, weight, serum parathyroid hormone (PTH), and total cholesterol (TC) between the death group and the survival group (all P>0.05). The treatment time, neutrophil count, red blood cell volume distribution width (RDW), ALP, blood uric acid (UA), blood calcium, MHR and creatinine in the death group were all higher than those in the survival group (all P<0.05), while the lymphocyte count was lower than that in the survival group ( P<0.05). The Cox risk model showed that MHR, ALP, treatment duration, neutrophil count, lymphocyte count, RDW, UA, and creatinine were independent risk factors for all-cause mortality in PD patients ( OR=1.578, 2.881, 1.021, 1.122, 1.476, 2.231, 1.018, 1.008, all P<0.05); Pearson correlation analysis revealed that the survival time of PD patients was negatively correlated with MHR and ALP ( r=-0.305, -0.246, all P<0.05). Conclusions:The levels of MHR and ALP are closely related to the risk of all-cause mortality in PD patients and are independent risk factors for all-cause mortality in patients.
