The value of the monocyte to lymphocyte ratio in predicting the prognosis of patients with liver cirrhosis complicated with esophageal and gastric varices
10.3760/cma.j.cn431274-20241225-01927
- VernacularTitle:单核细胞与淋巴细胞比值预测肝硬化合并食管胃静脉曲张患者预后
- Author:
Wei CHEN
1
;
Yu LI
;
Ying CHEN
;
Qingqing FANG
;
Xiaojuan LI
;
Xinxin XU
;
Rui LI
Author Information
1. 苏州大学附属第一医院消化内科，苏州 215006
- Publication Type:Journal Article
- Keywords:
Monocytes;
Lymphocytes;
Liver cirrhosis;
Esophageal and gastric varices
- From:
Journal of Chinese Physician
2025;27(4):497-501
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application value of the new inflammatory index in predicting the prognosis of patients with liver cirrhosis complicated with esophageal and gastric varices.Methods:This study was a single-center cross-sectional study. Patients who were hospitalized in the Department of Gastroenterology of Minhang Hospital, Fudan University due to liver cirrhosis combined with esophageal and gastric varices from January 2019 to February 2024 were included. All patients were diagnosed clearly based on clinical data, laboratory tests and imaging examination results. According to the results of the first fasting blood routine test after the patient′s admission, the monocyte/lymphocyte ratio (MLR), neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and systemic immune inflammation index (SII) were calculated. Multivariate Cox regression analysis was used to screen the independent risk factors affecting the prognosis of patients with liver cirrhosis complicated with esophagogastric varices. Receiver operating characteristic (ROC) curve analysis was used to determine the optimal cutoff value of MLR on survival. Kaplan-Meier survival analysis was used to compare the survival differences between patients with MLR>0.33 and those with MLR≤0.33.Results:A total of 177 patients were included, among which 155 were in the survival group and 22 were in the death group. The results of multivariate Cox regression analysis indicated that MLR was an independent risk factor for the prognosis of patients with liver cirrhosis complicated with esophageal and gastric varices [ HR=5.16(95% CI: 1.39-19.15), P=0.014]. The Kaplan-Meier survival curve analysis results showed that the survival rate of patients in the MLR>0.33 group was significantly lower than that in the MLR≤0.33 group (80.90% vs 94.32%, P=0.012). Stratified analysis showed that in patients who did not receive endoscopic intervention, MLR was closely related to prognosis. Conclusions:MLR can be used as an independent risk factor for the prognosis of patients with liver cirrhosis complicated with esophageal and gastric varices, which is helpful for clinicians to conduct risk assessment and thereby formulate personalized treatment strategies.
