The application of near-infrared spectroscopy monitoring in the diagnosis of necrotizing enterocolitis in extremely/very low birth weight infants
10.3760/cma.j.cn431274-20240408-00609
- VernacularTitle:近红外光谱监测在极/超低出生体重儿坏死性小肠结肠炎诊断中的应用
- Author:
Jinghua ZHANG
1
;
Ruilian GUAN
1
;
Hongmei ZOU
1
Author Information
1. 广州市妇女儿童医疗中心新生儿科，广州 510623
- Publication Type:Journal Article
- Keywords:
Infant, very low birth weight;
Enterocolitis, necrotizing;
Spectroscopy, near-infrared
- From:
Journal of Chinese Physician
2025;27(4):556-560
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the application of near-infrared spectroscopy monitoring in the diagnosis of necrotizing enterocolitis (NEC) in extremely/very low birth weight infants.Methods:Extremely/very low birth weight infants suspected of having NEC who were hospitalized in the Neonatal Intensive Care Unit of Guangzhou Women and Children′s Medical Center from September 2019 to November 2021 were selected as the research subjects. The regional intestinal oxygen saturation (rintSO 2) and regional cerebral oxygen saturation (rcSO 2) of the children within 72 hours after the onset were monitored by near-infrared spectrometer. The mean values of rintSO 2 and rcSO 2, intestinal fractional tissue oxygen extraction (intFTOE), and splanchnic-cerebral oxygenation ratio (SCOR) during the monitoring period were calculated. According to whether NEC was diagnosed or not, the patients were divided into the non-NEC group and the NEC group. The NEC group was further divided into the common NEC group and the severe NEC group. The rintSO 2, rcSO 2, intFTOE and SCOR of each group were compared. Results:A total of 78 cases were included, including 50 cases in the non-NEC group and 28 cases in the NEC group. Among them, there were 17 cases in the common NEC group and 11 cases in the severe NEC group. The rcSO 2 in the NEC group was lower than that in the non-NEC group (65.2±6.1 vs 73.2±7.0), and the SCOR was higher than that in the non-NEC group (0.88±0.05 vs 0.81±0.07), and the differences were statistically significant (all P<0.05). There was no statistically significant difference in rintSO 2 and intFTOE between the two groups (all P>0.05). Both rintSO 2 and rcSO 2 in the severe NEC group were lower than those in the common NEC group [(52.0±4.6 vs 61.2±5.0) and (60.3±3.8 vs 68.3±5.0)], and intFTOE was higher than that in the common NEC group (0.46±0.05 vs 0.36±0.06). The differences were all statistically significant (all P<0.05). There was no statistically significant difference in SCOR between the two groups (all P>0.05). Conclusions:The monitoring values of near-infrared spectroscopy are correlated with the incidence of NEC in extremely/very low birth weight infants. Lower rcSO 2 and higher SCOR are helpful for identifying NEC, while lower rintSO 2, rcSO 2 and higher intFTOE are helpful for identifying severe NEC.
