Research progress of nucleic acid aptamer AS1411 in tumor molecular imaging
10.3760/cma.j.cn431274-20240328-00527
- VernacularTitle:核酸适配体AS1411在肿瘤分子影像学中的研究进展
- Author:
Wenpeng HUANG
1
;
Xinyao SUN
1
;
Xiaoyue ZHANG
1
;
Qi YANG
1
;
Lele SONG
1
;
Lei KANG
1
Author Information
1. 北京大学第一医院核医学科，北京 100034
- Publication Type:Journal Article
- Keywords:
Aptamers, nucleotide;
Tumour;
Molecular imaging
- From:
Journal of Chinese Physician
2025;27(4):622-626
- CountryChina
- Language:Chinese
-
Abstract:
Nucleic acid aptamers are a type of single-stranded oligonucleotides screened through in vitro exponentially enriched ligand phylogenetic technology, and they can bind to various targets with high specificity and high affinity. AS1411 is a 26-base guanine-rich DNA aptamer, and its target nucleolin is widely distributed in multiple locations within the cell, including the nucleolus, nucleoplasm, cytoplasm and cell membrane. AS1411 demonstrates multiple advantages, such as weak immunogenicity, low toxicity, easy structural modification, and strong tissue penetration ability. Despite numerous challenges in the clinical transformation process, with the continuous advancement of molecular imaging technology, AS1411 has demonstrated great potential in the fields of targeted imaging and targeted delivery of cancer drugs. This article mainly focuses on the research progress of AS1411 in the field of molecular imaging, covering its applications in magnetic resonance imaging, fluorescence imaging and nuclear medicine imaging, etc.
