Exploration of the pathogenesis and treatment of pulmonary interstitial fibrosis secondary to systemic sclerosis based on the theory of sanjiao membranous channels
10.3969/j.issn.1006-2157.2025.05.007
- VernacularTitle:基于三焦膜性管道论探讨系统性硬化病继发肺间质纤维化的病机及治疗
- Author:
Yunlong SUN
1
;
Xiaomei ZHANG
;
Tianshu YANG
;
Yanni LI
;
Mengqian LI
;
Yuxin LAI
;
Xinlei TAN
;
Liangduo JIANG
Author Information
1. 北京中医药大学研究生院 北京 100029;北京中医药大学东方医院
- Publication Type:Journal Article
- Keywords:
systemic sclerosis;
pulmonary interstitial fibrosis;
theory of sanjiao(triple energizers)membranous channels;
viscera and bowels micro-membrane;
dredging and regulating triple energizers
- From:
Journal of Beijing University of Traditional Chinese Medicine
2025;48(5):646-651
- CountryChina
- Language:Chinese
-
Abstract:
Systemic sclerosis is an autoimmune rheumatic disease that often leads to multisystem diseases,frequently resulting in pulmonary interstitial fibrosis.According to the theory of sanjiao(triple energizers)membranous channels,sanjiao connects the five zang-organs and six fu-viscera internally and the skin,muscles,and bones externally.It serves as a four-way membranous channel that connects internal organs and external structures,linking with the micromembranes of organs and blood vessels.The pathogenesis of pulmonary interstitial fibrosis secondary to systemic sclerosis involves external cold obstructing the skin and interstitial layers,impairing the defense qi and defense yang,which originate in the essence of the kidney.This leads to weak defensive qi and kidney deficiency,causing stagnation in sanjiao's energy flow and disruption of water and gasification and loss of fluid,resulting in accumulation of dampness,phlegm,and blood stasis.These obstructive factors spread along sanjiao's membranous channels,leading to multiorgan micromembrane involvement and systemic damage.The lungs,which are in direct contact with the external environment,are particularly susceptible to invasion by external pathogens.When combined with stagnation of dampness,phlegm,and blood in the lungs,this leads to secondary pulmonary fibrosis,resulting in lung dysfunction.Continuous stagnation of sanjiao exacerbates the overall condition of the patient,leading to a mixed cold-heat imbalance.Treatment focuses on"unblocking,transforming,and regulating"to restore sanjiao function,promote qi and fluid circulation,invigorate blood,and adjust the cold-heat imbalance,ultimately restoring the overall condition of the patient.
