Disulfiram like reaction due to cefaclor
10.3760/cma.j.issn.1008-5734.2015.01.023
- VernacularTitle:头孢克洛致双硫仑样反应
- Author:
Huijuan WANG
1
;
Tao CAO
1
;
Zheng WANG
1
;
Yalin LI
1
;
Changyuan WANG
1
Author Information
1. 首都医科大学宣武医院急诊科, 北京,100053
- Publication Type:Journal Article
- Keywords:
Disulfiram;
Cefaclor
- From:
Adverse Drug Reactions Journal
2015;17(1):72-73
- CountryChina
- Language:Chinese
-
Abstract:
A 60-year-old male suddenly developed right limb weakness and disturbance of consciousness on process of drinking.One hour later,he was sent to the Emergency Department,Xuanwu Hospital of Capital Medical University.Physical examination showed blood pressure of 70/40 mmHg,heart rate of 112 beats/min,breathing rate of 20 times/min,sluggish light reflex,both upper limbs muscle strength of grade 0,Babinski sign of left side (+) and right side (±).His random blood glucose was 6.4 mmol/L and his cranial CT examination was normal.Electrocardiographic monitoring,oxygen inhalation,and drugs of raising blood pressure were given immediately.Two hours after visiting the emergency department,the patient developed vomiting and received Ⅳ naloxone 0.4 mg.About 5 hours after visiting emergency,the doctor was informed from the patient's family member that the patient might have taken cefaclor.Disulfiram-like reactions due to drinking after administration of cephalosporin antibiotics was considered.Then dexamethasone 5 mg intravenously was given and about 7 hours after visiting the emergency department,the patient's blood pressure was 90/50 mmHg,light reflex was sensitive,muscle strength was grade 5,and bilateral babinski signs were negative.About 14 hours after visiting emergency department,the patient recovered.Then he said he had taken cefaclor for upper respiratory tract infection.
