Piperacillin sodium and tazobactam sodium-induced acute renal insufficiency
10.3760/cma.j.issn.1008-5734.2015.01.017
- VernacularTitle:哌拉西林钠他唑巴坦钠致急性肾功能不全
- Author:
Wenlin SHU
1
;
Zhijian SU
1
Author Information
1. 361009,厦门市中医院药剂科
- Publication Type:Journal Article
- Keywords:
Piperacillin;
Renal insufficiency,acute
- From:
Adverse Drug Reactions Journal
2015;17(1):63-64
- CountryChina
- Language:Chinese
-
Abstract:
An 88-year-old male patient with chronic obstructive pulmonary disease received an Ⅳ infusion of piperacillin sodium and tazobactam sodium 4.5 g twice daily for lung infection.His renal function was normal before drug use.On day 2,his serum urea and creatinine were 9.7 mmol/L and 164 μmol/L respectively,and 24 hour urine volume was 100 ml.He was given bladder irrigation but still had anuria.Acute renal insufficiency was considered.On day 3,the patient was treated with continuous renal replacement and piperacillin sodium and tazobactam sodium was stopped.On day 6,the urine volume increased to 2 150 ml.After an interval of 4 days,the patient received piperacillin sodium and tazobactam sodium (the same dosage as before) again for secondary lung infection.On the second day,the patient developed oliguria again and his serum urea and creatinine were 34.9 mmol/L and 382 μmol/L respectively.Piperacillin sodium and tazobactam sodium was withdrawn.Two days later,the urine volume increased obviously.Four days later,his serum urea and creatinine were 12.9 mmol/L and 168 μ mol/L respectively.
