Research progress of targeted lung denervation in the treatment of chronic obstructive pulmonary disease

VernacularTitle:靶向肺去神经支配术治疗慢性阻塞性肺疾病的研究进展
Author: Li XIONG ¹ ; Xianming ZHANG ¹
Author Information

1. 贵州医科大学附属医院呼吸与危重症医学科，贵阳　550004
Publication Type:Journal Article
Keywords: Pulmonary disease, chronic obstructive; Targeted pulmonary denervation
From: Journal of Chinese Physician 2025;27(2):313-317
CountryChina
Language:Chinese
Abstract: Chronic obstructive pulmonary disease (COPD) is characterized by incomplete reversible airflow obstruction, persistent airway inflammation, and systemic complications. Smoking is the main cause of COPD, while genetic factors, lung development and environmental stimuli play a role in the pathobiological process of COPD. The main drugs used to treat COPD are bronchodilators, including beta-2 agonists and long-acting anticholinergics (often used in combination with inhaled corticosteroids). However, research and clinical treatment in recent years have shown that frequent exacerbations of COPD exist even with the best medical treatment. Therefore, it is crucial to explore new treatments and technologies. Targeted lung denervation (TLD) is a new endoscopic therapy. This article reviews the mechanism of action, procedure and clinical application of TLD in COPD.