Advances in safe medication for bronchial asthma during pregnancy
10.3760/cma.j.issn.1008-5734.2014.02.015
- VernacularTitle:妊娠期支气管哮喘患者用药安全性研究进展
- Author:
Luxi JIANG
1
;
Yu CHEN
1
;
Li ZHAO
1
Author Information
1. 中国医科大学附属盛京医院呼吸科,沈阳,110004
- Publication Type:Journal Article
- Keywords:
Asthma;
Pregnancy;
Drug therapy
- From:
Adverse Drug Reactions Journal
2014;16(2):114-118
- CountryChina
- Language:Chinese
-
Abstract:
Medications in pregnancy can be divided into five categories (A,B,C,D,X).Bronchial asthma medications involve controller medication and relief medication.Inhaled corticosteroids are recommended as first-line controller medications for pregnant women with asthma.Low to medium dose of these drugs is generally safe and budesonide (category B) is considered to be the first choice.Short-acting β2-agonists are recommended as first-line relief medications for pregnant women with asthma and albuterol (category C) is the first choice.Systemic corticosteroids during pregnancy could cause elevated incidence of hypertension in pregnancy and preeclampsia.Besides,systemic corticosteroids in first trimester of pregnancy could induce occurrence of fetal cleft lip and cleft palate.Leukotriene modifier,cromolyn,and nedocromil have generally been established as safe to mothers and infants,but none of them is the first choice.Low dose theophylline for mild persistent asthma during pregnancy can be chosen,but serum concentrations must be monitored,and theophylline is not the first choice either.The use of long-acting β2-agonists during pregnancy alone has no marked effect on fetal growth and development while the safety to mothers remains to be further investigated.Poor asthma control can lead to hypoxia in pregnant women and it can cause much harm to the mothers and infants.It appears that the risk of consequences of poorly controlled asthma is higher than the adverse effects of asthma medications.In a word,asthma therapy in pregnancy should firstly weight the advantages and disadvantages.Choice of appropriate medication is critical for ensuring maternal and infant health.
