Efficacy and safety of human serum albumin treatment in patients with ascites due to cirrhosis: a Meta-analysis
10.3760/cma.j.issn.1008-5734.2014.02.012
- VernacularTitle:人血白蛋白治疗肝硬化腹水疗效与安全性的Meta分析
- Author:
Hanqiu ZHAN
1
;
Hui LIU
1
;
Na SUN
1
Author Information
1. 100015,首都医科大学附属北京地坛医院药剂科
- Publication Type:Journal Article
- Keywords:
Albumins;
Cirrhosis;
Ascites;
Meta-analysis
- From:
Adverse Drug Reactions Journal
2014;16(2):100-106
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of human serum albumin in treatment of patients with ascites due to cirrhosis.Methods Cochrane Library,PubMed,EMBase,Web of Science,CBM,CNKI,VIP,Wanfang Database were searched by using keywords "ascites","albumin","cirrhosis" and "randomized controlled trials".The full text papers of randomized controlled trials (RCT) about human albumin treatment in patients with ascites due to cirrhosis were collected.The articles were selected and evaluated according to the inclusion criteria.The related information was statistically analyzed with RevMan 5.2 software,the relative risk (RR) and 95％ confidence intervals (CI) were calculated.The patients in experimental group received Ⅳ infusion of human serum albumin.The patients in control group received isotonic 0.9％ sodium chloride injection or artificial colloid (such as hetastarch,dextran,polygeline etc.) or no drugs.The efficacy and safety were compared between the 2 groups.Results A total of 688 related articles were searched and 13 RCT were enrolled into the study finally.There were 11 articles in English and 2 in Chinese.A total of 1 152 patients were entered in the study.The results of Meta-analysis showed that the incidence of hyponatremia in the experimental group (7.67％) was lower than that in the control group (14.66％),the difference was statistically significant(RR =0.60,95％ CI:0.41 ～ 0.88,P =0.008).The differences of the ascites regression rates (91.67％ vs.88.44％),the incidences of renal injury (5.12％ vs.6.93％),the incidences of infection (5.04％ vs.4.93％),the incidences of hepatic encephalopathy (5.90％ vs.5.00％),the incidences of hemorrhage of digestive tract (2.57％ vs.2.73％),the incidences of hyperpotassemia (1.09％ vs.6.45％),the rehospitalization rates (52.15％ vs.61.82％),the rehospitalization rates due to ascites (38.68％ vs.41.85％),the hospital mortality (3.80％ vs.4.54％),and the total mortality rates (21.40％ vs.24.83％) between the experimental group and the control group were not statistically significant (all P ＞ 0.05).The difference of incidence of adverse reactions between the experimental group and the control group (3.13％ vs.3.05％) was not statistically significant (P =0.97).Conclusion The present study can not demonstrate the obvious differences in curative effect and safety between the therapies of Ⅳ infusion of human serum albumin and artifical colloid or chloride in treatment of patients with ascites due to cirrhosis.
