A case of epstein-barr virus positive nasopharyngeal large cell neuroendocrine carcinoma and literature review
10.3760/cma.j.cn431274-20240908-01388
- VernacularTitle:EB病毒阳性鼻咽部大细胞神经内分泌癌1例并文献复习
- Author:
Yilei ZHANG
1
;
Ling CHU
1
Author Information
1. 中南大学湘雅三医院病理科，长沙 410013
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Large cell neuroendocrine carcinoma;
Epstein-barr virus
- From:
Journal of Chinese Physician
2025;27(2):257-260
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To share the diagnosis and treatment of a case of epstein-barr virus positive nasopharyngeal large cell neuroendocrine carcinoma.Methods:The clinical data of a patient with epstein-barr virus positive nasopharyngeal large cell neuroendocrine carcinoma admitted to the Third Xiangya Hospital of Central South University in October 2020 were retrospectively analyzed, and the literature was reviewed to analyze the characteristics of the case, distinguish it from similar cases, and summarize the diagnosis experience.Results:The patient, a 53 year old male, was diagnosed with large cell neuroendocrine carcinoma after imaging examination revealed a mass of the nasopharynx. The patient underwent endoscopic excisional biopsy of the mass, and microscopic examination, immunohistochemistry, and in-situ hybridization for EBV were performed.Conclusions:Large cell neuroendocrine carcinoma expresses markers of pancytokeratins (CK), synaptophysin (Syn), chromogranin A (CgA), and nerve cell adhesion molecule (CD56). When morphologically considered as large cell neuroendocrine carcinoma, ancillary findings including immune markers and in-situ hybridization for EBV support the diagnosis of EBV-positive large cell NEC, and the treatment regimen is mainly-followed by radiotherapy and chemotherapy.
