Differences in human papillomavirus typing and viral load in patients with condyloma acuminatum of different genders and their correlation with disease and prognosis
10.3760/cma.j.cn431274-20240321-00468
- VernacularTitle:不同性别尖锐湿疣患者HPV分型和病毒载量的差异及与病情和预后的相关性
- Author:
Ning SUN
1
;
Zhonghai WANG
;
Huishu HUANG
Author Information
1. 大庆市第四医院皮肤性病科，大庆 163712
- Publication Type:Journal Article
- Keywords:
Condylomata acuminata;
Human papillomavirus;
Genotype;
Viral load
- From:
Journal of Chinese Physician
2025;27(2):246-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To analyze the difference of human papillomavirus (HPV) typing and viral load between male and female patients with condyloma acuminatum, and to explore the correlation with the disease condition and prognosis of patients with condyloma acuminatum of different genders.Methods:A total of 123 male and 116 female HPV-positive patients with condyloma acuminatum admitted to the Daqing Fourth Hospital and the Acheng District Traditional Chinese Medicine Hospital of Harbin from January 2020 to December 2022 were selected as the study objects, and the differences in HPV typing and viral load between the two groups of patients with different genders were compared. The relationship between HPV typing and viral load and the condition and prognosis of condyloma acuminatum was analyzed.Results:The detection rate of low-risk HPV in male patients was higher than that of female patients, and the detection rate of high-risk HPV was lower than that of female patients, with statistical significance (χ 2=20.346, P<0.001; χ 2=8.880, P=0.003); The HPV infection types were mostly low-risk single infection in male patients and multiple infection in female patients (χ 2=17.651, P<0.001). The viral loads of low-risk HPV6, 11 and 81 in male patients were higher than those in female patients (all P<0.05). The viral loads of high-risk HPV16, 18, 52, 53, 58 and 66 in female patients were higher than those in male patients (all P<0.05). There was no significant difference in viral load of other HPV types between male and female patients (all P>0.05). The proportion of >10 warts in male and female patients with high viral load, the proportion of warts in urethra, cervix, anal canal and other non-external genitalia and the incidence of genital herpes were significantly higher than those of same sex patients with low viral load (all P<0.05). The total treatment response rate of male and female patients with high viral load (77.4%, 72.5%) was significantly lower than that of the same sex group with low viral load (94.3%, 91.5%) (χ 2=7.637, P=0.007; χ 2=6.366, P=0.017). The total recurrence rates of male patients were high-risk single infection, multiple infection and low-risk single infection from high to low, while the total recurrence rates of female patients were multiple infection, high-risk single infection and low-risk single infection from high to low, with statistical significance (χ 2=13.989, P=0.001; χ 2=10.292, P=0.006). Conclusions:There are differences in HPV typing distribution and viral load between male and female patients with condyloma acuminatum. HPV typing and viral load are correlated with the condition and prognosis of male and female patients with condyloma acuminatum.
