Exploration on the Role of Autophagy in Diabetic Cardiomyopathy Based on the Theory of Healthy Qi and Pathogenic Factors and Chinese Materia Medica Intervention
10.19879/j.cnki.1005-5304.202405325
- VernacularTitle:基于正邪理论探讨自噬在糖尿病心肌病中的作用及中药干预
- Author:
Yao ZHANG
1
;
Meng YANG
1
;
Yunfeng YU
1
;
Zhixi HU
1
Author Information
1. 湖南中医药大学中医学院,湖南 长沙 410208
- Publication Type:Journal Article
- Keywords:
diabetic cardiomyopathy;
autophagy;
theory of healthy qi and pathogenic factors;
Chinese materia medica
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(7):14-18
- CountryChina
- Language:Chinese
-
Abstract:
The struggle between healthy qi and pathogenic factors runs through the whole process of the formation and development of diabetic cardiomyopathy(DCM),and autophagy is the main regulator of cardiac homeostasis and function.Based on the theory of healthy qi and pathogenic factors,the autophagy state of DCM was understood.In the early stage of DCM,it is mainly characterized by deficiency of healthy qi and supplemented by pathogenic excess.In the middle stage,it is characterized by deficiency of healthy qi and pathogenic excess.In the late stage,it is mainly characterized by pathogenic excess and supplemented by deficiency of healthy qi.TCM clinical practice adheres to the principle of"strengthening the healthy qi and eliminating pathogenic factors",which aims to restore the dynamic balance of autophagy in the body by adjusting the balance between healthy qi and pathogenic factors,and ultimately improve the prognosis of DCM.This article took the theory of healthy qi and pathogenic factors as the starting point,and elaborated on the role of autophagy in the development of DCM from macro and micro perspectives.It explored Chinese materia medica intervention plans for different stages of DCM,providing theoretical reference for the regulation of autophagy in DCM by TCM.
