Adverse drug reactions induced by long term use of proton pump inhibitors
10.3760/cma.j.issn.1008-5734.2015.03.013
- VernacularTitle:长期使用质子泵抑制剂的不良反应
- Author:
Xiaobei SI
1
;
Yu LAN
1
Author Information
1. 100035,北京积水潭医院消化科
- Publication Type:Journal Article
- Keywords:
Proton pump inhibitors;
Long-term care;
Drug-related side effects and adverse reactions
- From:
Adverse Drug Reactions Journal
2015;(3):218-221
- CountryChina
- Language:Chinese
-
Abstract:
The proton pump inhibitors( PPI)are widely used as the treatment of choice in acid-related diseases in clinic. Long term use of PPI may further induce abnormal absorption of nutrition( vitamin B12 ,calcium,iron,magnesium and other minerals ),abnormal proliferation of gastrointestinal mucosa, infection,and abnormal bone metabolism( osteoporosis and bone fracture ),and so on. Most studies on safety of long term use of PPI are retrospective cohorts or case-control studies. More prospective randomized controlled trials should be performed and good clinical evidences should be obtained for reasonable and safe use of PPI.
