Study on the Fingerprint and Prediction of Quality Markers of Qiangshen Oral Liquid
10.19879/j.cnki.1005-5304.202501484
- VernacularTitle:强身口服液指纹图谱研究及质量标志物预测
- Author:
Xin YANG
1
;
Yanmei LIU
;
Yan ZHANG
;
Xiaowu XIAO
;
Ting HONG
Author Information
1. 萍乡市食品药品检验所,江西 萍乡 337000
- Publication Type:Journal Article
- Keywords:
Qiangshen Oral Liquid;
fingerprint spectrum;
quality marker;
network pharmacology;
molecular docking
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(7):127-133
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a fingerprint spectrum for Qiangshen Oral Liquid;To predict its quality markers combined with network pharmacology.Methods HPLC-ELSD method was used to establish fingerprint spectrum of Qiangshen Oral Liquid,and common peaks were identified.Its targets and related pathways were predicted through network pharmacology.A component-target-pathway network was constructed,and molecular docking verification was performed to analyze the quality markers of Qiangshen Oral Liquid.Results The HPLC fingerprint spectrum of Qiangshen Oral Liquid was established.20 common peaks were identified and belonged to all prescription drug tastes.13 chromatographic peaks were located using reference standards.The similarity evaluation showed that the similarity of 19 batches of Qiangshen Oral Liquid ranged from 0 to 0.995.Network pharmacology identified 45 key targets related to 13 components,and KEGG enrichment analysis obtained 151 pathways.A component-target-pathway network was constructed,predicted that calycosin-7-O-glucoside,ginsenoside Rg1,ginsenoside Re,ginsenoside Rf,ginsenoside Rb1,astragaloside Ⅳ,ginsenoside Rd,ginsenoside Rb2,astragaloside Ⅱ,astragaloside Ⅰ,schisandrin A and panaxatriol were quality markers for Qiangshen Oral Liquid.Conclusion The fingerprint spectrum of Qiangshen Oral Liquid was established,and quality markers were predicted preliminarily,providing a reference for its standard establishment and quality evaluation.
