Correlation between serum uric acid and incident chronic kidney disease in middle-aged and elderly Chinese population and gender differences
10.3969/j.issn.1672-8467.2025.03.001
- VernacularTitle:中国中老年人群血尿酸与新发慢性肾脏病的相关性及性别差异
- Author:
Qing MIN
1
;
Han ZHANG
;
Zi-yan SHEN
;
Shi-qi LYU
;
Cheng ZHU
;
Xiao-yan ZHANG
;
Xiao-qiang DING
Author Information
1. 复旦大学附属中山医院肾内科 上海 200032;新疆维吾尔自治区喀什地区第二人民医院老年医学科 喀什 844000
- Publication Type:Journal Article
- Keywords:
serum uric acid(SUA);
chronic kidney disease(CKD);
gender differences;
middle-aged and elderly population
- From:
Fudan University Journal of Medical Sciences
2025;52(3):317-325
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between serum uric acid(SUA)levels and incident chronic kidney disease(CKD)in middle-aged and elderly Chinese population and gender differences.Methods Based on the longitudinal survey data of China Health and Retirement Longitudinal Study from 2011 to 2015,the CKD-Epidemiology Collaboration cystatin C formula was used to estimate the glomerular filtration rate(eGFR),and 4 119 participants with normal renal function(eGFR≥60 mL·min-1·1.72 m-2)at baseline were included.Incident CKD was defined as eGFR<60 mL·min-1·1.72 m-2 at the follow-up in 2015.Logistic regression analysis was used to analysis the association of SUA levels at baseline and incident CKD among different genders.Restricted cubic spline analysis was used to analyze the dose-response relationship.Results After 4-year follow-up,127 participants developed incident CKD,including 57 males and 70 females.Multivariate Logistic regression analysis showed that elevated SUA levels were independently associated with the risk of incident CKD(OR=1.532,P<0.001).For each 1 mg/dL increase in SUA,the risk of incident CKD increased by 33.6%in males(OR=1.336,P=0.012)and 77.5%in females(OR=1.755,P<0.001).Restricted cubic spline analysis showed a linear positive correlation between SUA levels and incident CKD in both males and females.Participants were divided into four groups according to SUA quartiles(Q1-Q4).Multivariate Logistic regression analysis indicated a significant increase in the risk of incident CKD in Q3 group(3.75 mg/dL4.43 mg/dL)compared with Q1 group in females(Q3 group:OR=2.571,P=0.045;Q4 group:OR=3.666,P=0.005).Conclusion SUA is an independent risk factor for incident CKD in the middle-aged and elderly population.In females,serum uric acid levels exceeding 3.75 mg/dL are associated with an increased risk of incident CKD.
