Diagnostic value of ultrasound parameters of umbilical artery combined with Hcy and D-dimer in FGR
10.3969/j.issn.1672-8270.2025.06.012
- VernacularTitle:脐动脉超声参数联合同型半胱氨酸和D-二聚体指标在胎儿生长受限中的诊断价值
- Author:
Yang WANG
1
;
Fanrui MENG
;
Ying ZHANG
;
Jinhui ZHANG
Author Information
1. 唐山市妇幼保健院超声医学科 唐山 063000
- Publication Type:Journal Article
- Keywords:
Umbilical artery ultrasound;
Homocysteine;
D-dimer;
Fetal growth restriction
- From:
China Medical Equipment
2025;22(6):59-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the diagnostic value of ultrasound parameters of umbilical artery(UA)combined with homocysteine(Hcy)and D-dimer in fetal growth restriction(FGR).Methods:A total of 87 pregnant women with FGR who admitted to Tangshan Maternal and Child Health Care Hospital from June 2020 to June 2023 were included in the FGR group,and 109 normal pregnant women were included in the normal control group during the same period.Color Doppler ultrasound was used to measure UA parameters of fetal in normal control group and FGR group.The serums of pregnant women were collected to detect Hcy and D-dimer levels.The area under curve(AUC)of receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of UA ultrasound parameters,which included pulsation index(PI),resistance index(RI),systolic/diastolic(S/D),combined with Hcy and D-dimer for FGR.Results:The PI,RI,S/D,Hcy and D-dimer levels of UA ultrasound parameters of FGR group were significantly higher than these of normal control group,and the differences were statistically significant(t=6.325,7.380,8.455,5.267,7.686,P<0.05).The ROC analysis indicated that AUC values of PI,RI,S/D,Hcy and D-dimer were respectively 0.742,0.749,0.805,0.702 and 0.792 in alone diagnosing FGR.The AUC value of combined diagnosis was significantly higher than the alone diagnosis of each indicator,and the differences were statistically significant(Z=2.978,0.190,0.128,0.231,0.141,P<0.05).Conclusion:UA ultrasound parameters,Hcy and D-dimer levels show significant changes in FGR,and all of them can be used to screen FGR.The effectiveness of the combined screening is more significant.
