Progress of research and application of MS technology in clinical laboratory
10.3969/j.issn.1672-8270.2025.06.031
- VernacularTitle:质谱技术在临床检验中的研究及应用进展
- Author:
Guihong LIU
1
;
Weibo LI
1
;
Huixia LIN
1
;
Shuangxi FENG
1
;
Jianhua ZHANG
1
Author Information
1. 广州市社会福利院康复医院检验室 广州 510520
- Publication Type:Journal Article
- Keywords:
Clinical laboratory;
Mass spectrometry imaging(MSI)technique;
Matrix assisted laser desorption ionization time-of-flight mass spectrometry technology(MALDI-TOF-MS);
Inductively coupled plasma mass spectrometry(ICP-MS)technique;
Cytometry by time-of-fligh
- From:
China Medical Equipment
2025;22(6):163-169
- CountryChina
- Language:Chinese
-
Abstract:
Mass spectrometry(MS)is one of the core technology in the field of clinical laboratory,which has a series of advantages include high sensitivity,high specificity,and the simultaneous analysis of multi-components.It shows great potential in metabolite detection,proteomic analysis,etc.,which can provide new pathways for early diagnosis and personalized treatment of complex diseases.In recent years,the research of MS technique appears rapid development trend in the field of clinical laboratory.This paper systematically combed the application status and research progress of MS techniques in clinical laboratory,which include mass spectrometry imaging(MSI),matrix-assisted laser desorption/ionization time-of-flight mass spectrometry(MALDI-TOF MS),inductively coupled plasma mass spectrometry(ICP-MS),cytometry by time-of-flight(CyTOF),and liquid chromatography-tandem mass spectrometry(LC-MS/MS).It focused on their practical applications in disease diagnosis,efficacy assessment,and prognosis judgment,and it anatomized the faced bottlenecks and problems of current technique.Based on the frontline technological trends,it explore the innovative directions of integrating MS technique with emerging bioinformatics,microfluidics,etc.,so as to provide theoretical basis and practical reference for promoting the standardized and intelligent development of MS technique in clinical laboratory,and help its wide application in clinical diagnosis and treatment.
