Value of dynamic contrast-enhanced MRI combined with diffusion weighted imaging in differential diagnosis of benign and malignant prostate lesions in the peripheral zone
10.3969/j.issn.1002-1671.2025.05.020
- VernacularTitle:动态对比增强MRI结合扩散加权成像在外周带前列腺良恶性病变患者中的鉴别诊断价值
- Author:
Chang LI
1
;
Juan WANG
1
;
Guoyang FENG
1
;
Jingxin LIU
1
;
Mengyan LU
1
;
Longjun GUO
1
Author Information
1. 首都医科大学附属北京康复医院放射科,北京 100144
- Publication Type:Journal Article
- Keywords:
dynamic contrast-enhanced magnetic resonance imaging;
diffusion weighted imaging;
peripheral zone;
prostate;
benign and malignant lesions
- From:
Journal of Practical Radiology
2025;41(5):810-814
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the value of dynamic contrast-enhanced magnetic resonance imaging(DCE-MRI)combined with diffusion weighted imaging(DWI)in differential diagnosis of benign and malignant prostate lesions in the peripheral zone.Methods A total of 80 patients with prostate lesions in the peripheral zone were selected.With biopsy results as the gold standard,the patients were divided into benign prostate lesion group and malignant prostate lesion group.The value of DCE-MRI combined with DWI in differential diagnosis of benign and malignant prostate lesions in the peripheral zone was analyzed.Results Prostate-specific antigen(PSA)level in the malignant prostate lesion group was significantly higher than that in the benign prostate lesion group(P＜0.05).The Ktrans,Kep and Ve in the malignant prostate lesion group were significantly higher than those in the benign prostate lesion group(P＜0.05),and the apparent diffusion coefficient(ADC)value was significantly lower than that in the benign prostate lesion group(P＜0.05).According to the results of multivariate logistic regression analysis,the evaluation model was established.Receiver oper-ating characteristic(ROC)curve analysis indicated that the area under the curve(AUC)for distinguishing benign and malignant pros-tate lesions in the peripheral zone was 0.905,the sensitivity and specificity were 0.735 and 0.950.Pearson correlation analysis showed that the Ktrans,Kep and Ve were positively correlated with PSA level in the malignant prostate lesion group,while the ADC value was negatively correlated with PSA level(P＜0.05).Conclusion The quantitative parameters(Ktrans,Kep and Ve)of DCE-MRI and ADC value of DWI are independent influencing factors of malignant prostate lesions in the peripheral zone.The evaluation model construc-ted based on these factors has high value in the differential diagnosis of benign and malignant prostate lesions in the peripheral zone.
