Evaluation of neoadjuvant chemotherapy curative effect in patients with breast cancer by MRI
10.3969/j.issn.1002-1671.2025.05.011
- VernacularTitle:MRI对乳腺癌患者新辅助化疗治疗效果的评价
- Author:
Liangfeng YAO
1
;
Baoliang GUO
;
Hongyan HE
;
Xulong FAN
;
Cuishan LIANG
;
Gan TIAN
;
Yunneng CUI
Author Information
1. 佛山市妇幼保健院放射科,广东 佛山 528000
- Publication Type:Journal Article
- Keywords:
magnetic resonance imaging;
breast cancer;
neo-adjuvant chemotherapy
- From:
Journal of Practical Radiology
2025;41(5):767-770
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the value of MRI in evaluating the treatment efficacy of neoadjuvant chemotherapy(NAC)in breast cancer patients.Methods The clinical data of 130 patients with breast cancer were analyzed retrospectively.All patients under-went 4-8 cycles of NAC,with MRI examinations was performed before and after NAC treatment.Based on postoperative response eval-uation criteria in solid tumors(RECIST),the patients were categorized into effective and ineffective groups.The MRI related param-eters,early enhancement parameters and peak enhancement parameters before and after NAC were observed to evaluate the efficacy of MRI in evaluating the treatment efficacy of NAC in breast cancer.Results The sensitivity,specificity,and accuracy of MRI in evalua-ting the treatment efficacy of NAC in breast cancer were 96.74％,89.47％,and 94.62％,respectively.The Kappa value for consis-tency analysis between MRI and postoperative pathology reached 0.869,indicating good agreement.Receiver operating characteristic(ROC)curve analysis showed that the area under the curve(AUC)for MRI in predicting the treatment efficacy of NAC in breast cancer was 0.935[95％ confidence interval(CI)0.831-0.981].Significant differences were observed between the effective and ineffec-tive groups in early and peak enhancement parameters before and after NAC(P＜0.05).Conclusion MRI can effectively assesses the treatment efficacy of NAC in breast cancer patients,demonstrating high value in clinical applications.
